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norskBlar i forfatter "Müller, Fredrik"
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Association of body mass index with COVID-19 related in-hospital death
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-29)Background: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19.<p> <p>Methods: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. <p>Results: Data from 12,137 ... -
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals.<p> <p>Methods: We measured inflammatory mediators, antibodies to the ... -
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-15)Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from ... -
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-25)<i>Background</i> - A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin system, as well as inflammatory mechanisms have been suggested to play a role. ACE2 is abundant in the gut and associated with gut microbiota composition. We ... -
Elevated plasma sTIM-3 levels in patients with severe COVID-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)<i>Background</i> - The pathogenesis of coronavirus disease 2019 (COVID-19) is still incompletely understood, but it seems to involve immune activation and immune dysregulation.<p> <p><i>Objective</i> - We examined the parameters of activation of different leukocyte subsets in COVID-19–infected patients in relation to disease severity.<p> <p><i>Methods</i> - We analyzed plasma levels of ... -
An Estimate of the Burden of Fungal Disease in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-21)The aim of this study was to examine the burden of fungal disease in Norway, contributing to a worldwide effort to improve awareness of the needs for better diagnosis and treatment of such infections. We used national registers and actual data from the Departments of Microbiology from 2015 and estimated the incidence and/or prevalence of superficial, allergic and invasive fungal disease using published ... -
High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)Background. Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but data on their regulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We thus investigated the levels of these chemokines in COVID-19 ... -
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-07)We prospectively studied the consequences of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in a cohort of children with cystic fibrosis (CF) and a cohort of children with cancer compared to healthy children with no or low antibiotic exposure. The study was conducted in Norway in a low resistance prevalence setting. Sixty longitudinally collected faecal ... -
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-10)In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a ... -
Mapping the human genetic architecture of COVID-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-08)The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal ... -
Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-31)The Omicron variant of SARS-CoV-2 spreads more easily than earlier variants, possibly as a result of a higher viral load in the upper respiratory tract and oral cavity. Hence, we investigated whether the Omicron variant generates a higher viral load than that of the Delta variant in saliva and nasopharynx. Both specimens were collected from 52 Omicron and 17 Delta cases at two time points one week ... -
Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DL<sub>CO</sub>), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, ... -
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-18)Background - T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown.<p> <p>Objectives - To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19.<p> <p>Methods ... -
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-17)The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated to trigger this detrimental process. The complement system is a key player in innate immunity. Despite a few reports of local complement activation, there is a lack of evidence that the degree of systemic complement ...
